UHRF1 Contributes to DNA Damage Repair as a Lesion Recognition Factor and Nuclease Scaffold

UHRF1 Contributes to DNA Damage Repair as a Lesion Recognition Factor and Nuclease Scaffold

We identified ubiquitin-like with PHD and RING finger domain 1 (UHRF1) as a binding factor for DNA interstrand crosslink (ICL) lesions through affinity purification of ICL-recognition activities. UHRF1 is recruited to DNA lesions in vivo and binds directly to ICL-containing DNA. UHRF1-deficient cell...

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Bibliographic Details
Main Authors: Yanyan Tian, Manikandan Paramasivam, Gargi Ghosal, Ding Chen, Xi Shen, Yaling Huang, Shamima Akhter, Randy Legerski, Junjie Chen, Michael M. Seidman, Jun Qin, Lei Li
Format: Article
Language:English
Published: Elsevier 2015-03-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715003071

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