Effect of adjuvant therapy of Weisu Granule on Cyclooxygenase-2, E-cadherin, procalcitonin and gastrin in patients with chronic gastritis

• Main Authors: Xin Chen, An-Ping Wang
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2018-01-01
• Series: Journal of Hainan Medical University
• Subjects: Chronic gastritis; Wei Su granule; Triple therapy; Cyclooxygenase-2; E-cadherin; Procalcitonin; Gastrin
• Online Access: http://www.hnykdxxb.com/PDF/201801/05.pdf

Objective: To observe the effects of Weisu Granule combined with triple therapy (esomeprazole, tinidazole and amoxicillin) on gastric mucosal cyclooxygenase-2 (COX-2) and cadherin E (E-cadherin), serum procalcitonin (PCT) and gastrin in patients with chronic gastritis. Methods: A total of 90 patients with chronic gastritis were randomly divided into control group and observation group (n=45) according to the lottery method. Both groups were treated with conventional therapy. On this basis, the control group was treated with triple therapy. The observation group was treated with triple therapy combined with Wei Su granule. The levels of COX-2, E-cadherin, procalcitonin and gastrin in peripheral blood were measured before and after treatment in all subjects. Result: There was no significant difference in the levels of gastric mucosal COX-2 and E-cadherin between the two groups before treatment. After treatment, the levels of COX-2 and E-cadherin in both groups were significantly lower than those before treatment. And the observation group was lower than the control group after treatment. There was no significant difference in serum PCT and gastrin levels between the two groups before treatment. After treatment, the levels of PCT and gastrin in both groups were significantly lower than those before treatment. And the observation group was lower than the control group after treatment. Conclusion: Wei Su granule combined with triple therapy in the treatment of chronic gastritis, can effectively reduce the levels of COX-2, E-cadherin, PCT and gastrin, relieve the gastric mucosal injury and symptoms, which is a clinically effective treatment.