Effect of Eight Weeks of Aerobic and Aerobic-Resistance Trainings after Coronary Artery Bypass Grafting on Expression of CCL2 and CCL5 in Middle-Aged Men

• Main Authors: Najmatol sabah Alavizadeh, Amir Rashidlamir, Seyed Mahmoud Hejazi
• Format: Article
• Language: English
• Published: Golestan University of Medical Sciences 2021-01-01
• Series: Medical Laboratory Journal
• Subjects: cardiac rehabilitation; gene expression; mcp-1; rantes.
• Online Access: http://mlj.goums.ac.ir/article-1-1296-en.html

Background and objectives: Chemokines are a group of proteins involved in both innate and adaptive immunity with a significant role on homeostasis and immune system development. The present study aimed to evaluate effects of eight weeks of cardiopulmonary rehabilitation exercise after coronary artery bypass surgery on expression of chemokines CCL2 and CCL5 in peripheral blood mononuclear cells of middle-aged men. Methods: The study was performed on 45 middle-aged men that had undergone coronary artery bypass surgery. The subjects were randomly divided into three groups of control (n=15), aerobic exercise (n=15) and combined aerobic-resistance exercise (n=15). The trainings were performed three times a week for eight weeks at 60-75% of target heart rate. Fasting blood samples were collected 24 hours before the first training session and 48 hours after the last training session. Lymphocytes were separated by centrifugation. Change in gene expression was investigated by real time-PCR. Data were analyzed in SPSS (version 16) using one-way analysis of variance and Tukey’s post hoc test. Results: The eight week exercise training significantly decreased expression of CCL2 compared to the control group. Conclusion: Rehabilitation exercise can be an effective way to prevent, control or reduce atherosclerosis by lowering expression of CCL2 and CCL5.