Engineering a Cysteine-Deficient Functional Candida albicans Cdr1 Molecule Reveals a Conserved Region at the Cytosolic Apex of ABCG Transporters Important for Correct Folding and Trafficking of Cdr1

Engineering a Cysteine-Deficient Functional Candida albicans Cdr1 Molecule Reveals a Conserved Region at the Cytosolic Apex of ABCG Transporters Important for Correct Folding and Trafficking of Cdr1

Overexpression of the fungal pleiotropic drug resistance (PDR) transporter Cdr1 is a major cause of antifungal drug resistance in Candida albicans

Bibliographic Details
Main Authors: Golnoush Madani, Erwin Lamping, Richard D. Cannon
Format: Article
Language:English
Published: American Society for Microbiology 2021-02-01
Series:mSphere
Online Access:https://journals.asm.org/doi/10.1128/mSphere.01318-20
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spelling doaj-a4117ba924bb440dae74d230774e60dc2021-09-21T20:22:52ZengAmerican Society for MicrobiologymSphere2379-50422021-02-016110.1128/mSphere.01318-20Engineering a Cysteine-Deficient Functional Candida albicans Cdr1 Molecule Reveals a Conserved Region at the Cytosolic Apex of ABCG Transporters Important for Correct Folding and Trafficking of Cdr1Golnoush Madani0Erwin Lamping1https://orcid.org/0000-0002-4942-4782Richard D. Cannon2https://orcid.org/0000-0002-5398-2066Sir John Walsh Research Institute, Faculty of Dentistry, University of Otago, Dunedin, New ZealandSir John Walsh Research Institute, Faculty of Dentistry, University of Otago, Dunedin, New ZealandSir John Walsh Research Institute, Faculty of Dentistry, University of Otago, Dunedin, New Zealand Overexpression of the fungal pleiotropic drug resistance (PDR) transporter Cdr1 is a major cause of antifungal drug resistance in Candida albicanshttps://journals.asm.org/doi/10.1128/mSphere.01318-20
collection DOAJ
language English
format Article
sources DOAJ
author Golnoush Madani
Erwin Lamping
Richard D. Cannon
spellingShingle Golnoush Madani
Erwin Lamping
Richard D. Cannon
Engineering a Cysteine-Deficient Functional Candida albicans Cdr1 Molecule Reveals a Conserved Region at the Cytosolic Apex of ABCG Transporters Important for Correct Folding and Trafficking of Cdr1
mSphere
author_facet Golnoush Madani
Erwin Lamping
Richard D. Cannon
author_sort Golnoush Madani
title Engineering a Cysteine-Deficient Functional Candida albicans Cdr1 Molecule Reveals a Conserved Region at the Cytosolic Apex of ABCG Transporters Important for Correct Folding and Trafficking of Cdr1
title_short Engineering a Cysteine-Deficient Functional Candida albicans Cdr1 Molecule Reveals a Conserved Region at the Cytosolic Apex of ABCG Transporters Important for Correct Folding and Trafficking of Cdr1
title_full Engineering a Cysteine-Deficient Functional Candida albicans Cdr1 Molecule Reveals a Conserved Region at the Cytosolic Apex of ABCG Transporters Important for Correct Folding and Trafficking of Cdr1
title_fullStr Engineering a Cysteine-Deficient Functional Candida albicans Cdr1 Molecule Reveals a Conserved Region at the Cytosolic Apex of ABCG Transporters Important for Correct Folding and Trafficking of Cdr1
title_full_unstemmed Engineering a Cysteine-Deficient Functional Candida albicans Cdr1 Molecule Reveals a Conserved Region at the Cytosolic Apex of ABCG Transporters Important for Correct Folding and Trafficking of Cdr1
title_sort engineering a cysteine-deficient functional candida albicans cdr1 molecule reveals a conserved region at the cytosolic apex of abcg transporters important for correct folding and trafficking of cdr1
publisher American Society for Microbiology
series mSphere
issn 2379-5042
publishDate 2021-02-01
description Overexpression of the fungal pleiotropic drug resistance (PDR) transporter Cdr1 is a major cause of antifungal drug resistance in Candida albicans
url https://journals.asm.org/doi/10.1128/mSphere.01318-20
work_keys_str_mv AT golnoushmadani engineeringacysteinedeficientfunctionalcandidaalbicanscdr1moleculerevealsaconservedregionatthecytosolicapexofabcgtransportersimportantforcorrectfoldingandtraffickingofcdr1
AT erwinlamping engineeringacysteinedeficientfunctionalcandidaalbicanscdr1moleculerevealsaconservedregionatthecytosolicapexofabcgtransportersimportantforcorrectfoldingandtraffickingofcdr1
AT richarddcannon engineeringacysteinedeficientfunctionalcandidaalbicanscdr1moleculerevealsaconservedregionatthecytosolicapexofabcgtransportersimportantforcorrectfoldingandtraffickingofcdr1
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