Formulation and optimization of duloxetine hydrochloride buccal films: in vitro and in vivo evaluation

Formulation and optimization of duloxetine hydrochloride buccal films: in vitro and in vivo evaluation

Duloxetine hydrochloride (DH) is a serotonin–norepinephrine reuptake inhibitor (SSNRI) indicated for the treatment of depression. Duloxetine suffers from reduced oral bioavailability (≈50%) due to hepatic metabolism. This study aims to develop DH buccoadhesive films to improve its bioavailability. D...

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Bibliographic Details
Main Authors: Amr Mostafa El Sharawy, Marwa Hassan Shukr, Ahmed Hassen Elshafeey
Format: Article
Language:English
Published: Taylor & Francis Group 2017-01-01
Series:Drug Delivery
Subjects:
buccoadhesive films
duloxetine hydrochloride
mucoadhesion
drug release
accelerated stability
bioavailability
Online Access:http://dx.doi.org/10.1080/10717544.2017.1402216

Internet

http://dx.doi.org/10.1080/10717544.2017.1402216

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