Diversity Oriented Syntheses of Conventional Heterocycles by Smart Multi Component Reactions (MCRs) of the Last Decade

• Main Author: Heiner Eckert
• Format: Article
• Language: English
• Published: MDPI AG 2012-01-01
• Series: Molecules
• Subjects: multicomponent reaction; MCR; MFCR; I-MCR; isocyanide; heterocycle; diversity oriented synthesis; solvent-less synthesis; alternative energy; microwave
• Online Access: http://www.mdpi.com/1420-3049/17/1/1074/
• ISSN: 1420-3049

A collection of smart multicomponent reactions (MCRs) with continuative post condensation cyclizations (PCCs) is presented to construct conventional three- to seven-membered heterocyclic compounds in diversity oriented syntheses (DOS). These will provide a high degree of applying economical and ecological advantages as well as of practicability. Water, ionic liquids, and solvent-less syntheses as well as use of various forms of energy as microwave and ultrasonic irradiation are examined and discussed.