The role of the PLR–NLR combination in the prediction of the presence of Helicobacter pylori and its associated complications

• Main Authors: Mustafa Kaplan, Ihsan Ates, Mahmut Yuksel, Mehmet F Arikan, Gulden Aydog, Nesrin Turhan, Volkan Gökbulut, Ertugrul Kayacetin
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2018-01-01
• Series: The Saudi Journal of Gastroenterology
• Subjects: Chronic gastritis; Helicobacter pylori; intestinal metaplasia; lymphocyte; neutrophil
• Online Access: http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2018;volume=24;issue=5;spage=294;epage=300;aulast=

Background/Aim: The aim of this study was to investigate the role of the platelet-to-lymphocyte ratio (PLR)–neutrophil-to-lymphocyte ratio (NLR) combination, in the prediction of the presence of Helicobacter pylori (HP) and its associated complications in the gastrointestinal system. Patients and Methods: In all, 1289 patients who underwent esophagogastroduodenoscopy and biopsy for HP were included in the study. Results: The ratio of patients with moderate and severe chronic gastritis was higher in HP (+) group than HP (−) group. The ratio of patients with levels 1–3 atrophy and intestinal metaplasia was higher in HP (+) group. Compared with HP (−) group, HP (+) had higher PLR and NLR levels. The ratio of HP (+) patients was higher in high-risk group compared with low- and medium-risk groups. HP invasion stage, the intestinal metaplasia level, and the ratio of patients with atrophy level “3” were higher in high-risk group compared with low- and medium-risk groups. Regression analysis showed that the PLR–NLR combination was an independent risk factor for both HP presence and moderate and severe chronic gastritis. Conclusion: We found the PLR–NLR combination to be a good predictor of HP presence and gastrointestinal complications associated with HP.