Reduced SLIT2 is Associated with Increased Cell Proliferation and Arsenic Trioxide Resistance in Acute Promyelocytic Leukemia

Reduced SLIT2 is Associated with Increased Cell Proliferation and Arsenic Trioxide Resistance in Acute Promyelocytic Leukemia

The SLIT-ROBO axis plays an important role in normal stem-cell biology, with possible repercussions on cancer stem cell emergence. Although the Promyelocytic Leukemia (PML) protein can regulate <i>SLIT2</i> expression in the central nervous system, little is known about SLIT2 in acute pr...

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Main Authors: Isabel Weinhäuser, Diego A. Pereira-Martins, Cesar Ortiz, Douglas R. Silveira, Luíse A. A. Simões, Thiago M. Bianco, Cleide L. Araujo, Luisa C. Koury, Raul A. M. Melo, Rosane I. Bittencourt, Katia Pagnano, Ricardo Pasquini, Elenaide C. Nunes, Evandro M. Fagundes, Ana B. Gloria, Fábio Kerbauy, Maria de Lourdes Chauffaille, Armand Keating, Martin S. Tallman, Raul C. Ribeiro, Richard Dillon, Arnold Ganser, Bob Löwenberg, Peter Valk, Francesco Lo-Coco, Miguel A. Sanz, Nancy Berliner, Emanuele Ammatuna, Antonio R. Lucena-Araujo, Jan Jacob Schuringa, Eduardo M. Rego
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cancers
Subjects:
acute promyelocytic leukemia
SLIT2
treatment outcomes
ATRA
Online Access:https://www.mdpi.com/2072-6694/12/11/3134

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