Anti-Tubercular Properties of 4-Amino-5-(4-Fluoro-3- Phenoxyphenyl)-4<i>H</i>-1,2,4-Triazole-3-Thiol and Its Schiff Bases: Computational Input and Molecular Dynamics

Anti-Tubercular Properties of 4-Amino-5-(4-Fluoro-3- Phenoxyphenyl)-4<i>H</i>-1,2,4-Triazole-3-Thiol and Its Schiff Bases: Computational Input and Molecular Dynamics

In the present investigation, the parent compound 4-amino-5-(4-fluoro-3-phenoxyphenyl)-4<i>H</i>-1,2,4-triazole-3-thiol (<b>1</b>) and its Schiff bases <b>2</b>, <b>3</b>, and <b>4</b> were subjected to whole-cell anti-TB against H37Rv and...

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Bibliographic Details
Main Authors: Katharigatta N. Venugopala, Mahmoud Kandeel, Melendhran Pillay, Pran Kishore Deb, Hassan H. Abdallah, Mohamad Fawzi Mahomoodally, Deepak Chopra
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Antibiotics
Subjects:
<i>Mycobacterium tuberculosis</i>
triazole analogues
molecular dynamics studies
β-ketoacyl carrier protein synthase III (FABH)
β-ketoacyl ACP synthase I (KasA)
CYP121
Online Access:https://www.mdpi.com/2079-6382/9/9/559

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https://www.mdpi.com/2079-6382/9/9/559

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