Enantioselective three-component aminomethylation of α-diazo ketones with alcohols and 1,3,5-triazines

Enantioselective three-component aminomethylation of α-diazo ketones with alcohols and 1,3,5-triazines

Strategies for enantioselective α-aminomethylation of carbonyl compounds rely on the chiral activation of stable ketones substrate. Here, the authors report a rhodium/chiral phosphoric acid cooperative catalysis for the three-component reaction of α-diazo ketones with alcohols and 1,3,5-triazines vi...

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Main Authors: Jiuwei Che, Li Niu, Shikun Jia, Dong Xing, Wenhao Hu
Format: Article
Language:English
Published: Nature Publishing Group 2020-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15345-2
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spelling doaj-a3ef597d4cc44ac5b8b287977fd5add32021-05-11T08:20:29ZengNature Publishing GroupNature Communications2041-17232020-03-011111910.1038/s41467-020-15345-2Enantioselective three-component aminomethylation of α-diazo ketones with alcohols and 1,3,5-triazinesJiuwei Che0Li Niu1Shikun Jia2Dong Xing3Wenhao Hu4Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal UniversityShanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal UniversityGuangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen UniversityShanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal UniversityGuangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen UniversityStrategies for enantioselective α-aminomethylation of carbonyl compounds rely on the chiral activation of stable ketones substrate. Here, the authors report a rhodium/chiral phosphoric acid cooperative catalysis for the three-component reaction of α-diazo ketones with alcohols and 1,3,5-triazines via imine chiral activation.https://doi.org/10.1038/s41467-020-15345-2
collection DOAJ
language English
format Article
sources DOAJ
author Jiuwei Che
Li Niu
Shikun Jia
Dong Xing
Wenhao Hu
spellingShingle Jiuwei Che
Li Niu
Shikun Jia
Dong Xing
Wenhao Hu
Enantioselective three-component aminomethylation of α-diazo ketones with alcohols and 1,3,5-triazines
Nature Communications
author_facet Jiuwei Che
Li Niu
Shikun Jia
Dong Xing
Wenhao Hu
author_sort Jiuwei Che
title Enantioselective three-component aminomethylation of α-diazo ketones with alcohols and 1,3,5-triazines
title_short Enantioselective three-component aminomethylation of α-diazo ketones with alcohols and 1,3,5-triazines
title_full Enantioselective three-component aminomethylation of α-diazo ketones with alcohols and 1,3,5-triazines
title_fullStr Enantioselective three-component aminomethylation of α-diazo ketones with alcohols and 1,3,5-triazines
title_full_unstemmed Enantioselective three-component aminomethylation of α-diazo ketones with alcohols and 1,3,5-triazines
title_sort enantioselective three-component aminomethylation of α-diazo ketones with alcohols and 1,3,5-triazines
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-03-01
description Strategies for enantioselective α-aminomethylation of carbonyl compounds rely on the chiral activation of stable ketones substrate. Here, the authors report a rhodium/chiral phosphoric acid cooperative catalysis for the three-component reaction of α-diazo ketones with alcohols and 1,3,5-triazines via imine chiral activation.
url https://doi.org/10.1038/s41467-020-15345-2
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AT liniu enantioselectivethreecomponentaminomethylationofadiazoketoneswithalcoholsand135triazines
AT shikunjia enantioselectivethreecomponentaminomethylationofadiazoketoneswithalcoholsand135triazines
AT dongxing enantioselectivethreecomponentaminomethylationofadiazoketoneswithalcoholsand135triazines
AT wenhaohu enantioselectivethreecomponentaminomethylationofadiazoketoneswithalcoholsand135triazines
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