Derivation and Expansion of PAX7-Positive Muscle Progenitors from Human and Mouse Embryonic Stem Cells

Cell therapies treating pathological muscle atrophy or damage requires an adequate quantity of muscle progenitor cells (MPCs) not currently attainable from adult donors. Here, we generate cultures of approximately 90% skeletal myogenic cells by treating human embryonic stem cells (ESCs) with the GSK...

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Bibliographic Details
Main Authors: Michael Shelton, Jeff Metz, Jun Liu, Richard L. Carpenedo, Simon-Pierre Demers, William L. Stanford, Ilona S. Skerjanc
Format: Article
Language:English
Published: Elsevier 2014-09-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671114002318