In vitro activity of some flavonoid derivatives on human leukemic myeloid cells: evidence for aminopeptidase-N (CD13) inhibition, antiproliferative and cell death properties

In vitro activity of some flavonoid derivatives on human leukemic myeloid cells: evidence for aminopeptidase-N (CD13) inhibition, antiproliferative and cell death properties

Leukemia cells from patients with acute myeloid leukemia (AML) display high proliferative capacity and are resistant to death. Membrane-anchored aminopeptidase-N/CD13 is a potential drug target in AML<strong>. </strong>Clinical research efforts are currently focusing on targeted therapie...

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Bibliographic Details
Main Authors: Brigitte Bauvois, Daniel Dauzonne, Marion Piedfer, Santos Susin, Sandrine Bouchet
Format: Article
Language:English
Published: AIMS Press 2016-08-01
Series:AIMS Molecular Science
Subjects:
aminopeptidase-N
apoptosis
benzopyran
CD13
cell death
flavone
leukemia
metalloproteinase
proliferation
survival
Online Access:http://www.aimspress.com/Molecular/article/899/fulltext.html

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