Intra-articular delivery of flurbiprofen sustained release thermogel: improved therapeutic outcome of collagenase II-induced rat knee osteoarthritis

Intra-articular delivery of flurbiprofen sustained release thermogel: improved therapeutic outcome of collagenase II-induced rat knee osteoarthritis

Knee osteoarthritis (OA) is a common degenerative disease. Intra-articular administration of flurbiprofen is frequently employed in clinic to treat OA, while repeated injections are required because of the limited effective duration. To improve therapeutic outcome and prolong the treatment interval,...

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Bibliographic Details
Main Authors: Peinan Li, Haokun Li, Xiaohong Shu, Moli Wu, Jia Liu, Tangna Hao, Hongxia Cui, Lianjie Zheng
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Drug Delivery
Subjects:
flurbiprofen
thermosensitive gel
sustained release
intra-articular drug delivery
osteoarthritis
Online Access:http://dx.doi.org/10.1080/10717544.2020.1787555

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