Initiation of Experimental Temporal Lobe Epilepsy by Early Astrocyte Uncoupling Is Independent of TGFβR1/ALK5 Signaling

Initiation of Experimental Temporal Lobe Epilepsy by Early Astrocyte Uncoupling Is Independent of TGFβR1/ALK5 Signaling

Blood–brain barrier (BBB) dysfunction following brain insults has been associated with the development and progression of focal epilepsy, although the underlying molecular mechanisms are not fully elucidated yet. Activation of transforming growth factor beta (TGFβ) signaling in astrocytes by extrava...

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Bibliographic Details
Main Authors:	Lukas Henning, Christian Steinhäuser, Peter Bedner
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-05-01
Series:	Frontiers in Neurology
Subjects:	blood–brain barrier dysfunction albumin extravasation temporal lobe epilepsy gap junctional coupling astrocyte transforming growth factor beta
Online Access:	https://www.frontiersin.org/articles/10.3389/fneur.2021.660591/full

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