Tumor-Associated Neutrophils Dampen Adaptive Immunity and Promote Cutaneous Squamous Cell Carcinoma Development

Tumor-Associated Neutrophils Dampen Adaptive Immunity and Promote Cutaneous Squamous Cell Carcinoma Development

Cutaneous squamous cell carcinoma (cSCC) development has been linked to immune dysfunctions but the mechanisms are still unclear. Here, we report a progressive infiltration of tumor-associated neutrophils (TANs) in precancerous and established cSCC lesions from chemically induced skin carcinogenesis...

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Bibliographic Details
Main Authors: Sokchea Khou, Alexandra Popa, Carmelo Luci, Franck Bihl, Aida Meghraoui-Kheddar, Pierre Bourdely, Emie Salavagione, Estelle Cosson, Alain Rubod, Julie Cazareth, Pascal Barbry, Bernard Mari, Roger Rezzonico, Fabienne Anjuère, Veronique M. Braud
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cancers
Subjects:
neutrophils
cutaneous squamous cell carcinoma
PD-1
PD-L1
gene expression profile
Online Access:https://www.mdpi.com/2072-6694/12/7/1860

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