Potential Therapeutic Effects of Olea Europaea (Olive) Fruit Oil as neuroprotective agent against neurotocixity induced opioid

• Main Authors: Ummi Umaimah Ismail, Mohamad Halim Mohamad Shariff
• Format: Article
• Language: English
• Published: Shahid Beheshti University of Medical Sciences 2019-02-01
• Series: Journal of Cellular and Molecular Anesthesia
• Subjects: Morphine; Analgesics; Oxidative Stresses; Olive Oil; Olea Europaea; Antioxidants [Pharmacological Action]; Morphine Dependence; Molecular Medicine
• Online Access: http://journals.sbmu.ac.ir/jcma/article/view/24377

Morphine is used as analgesics medication to reduce pain by inhibting transmission of pain impulses especially in spinal cord and modulation of central pain processing. Unfortunately, the increase abuse of opioids such as morphine or heroin often leads to various side effects such as addiction, tolerance and physical dependence. One of the proposed mechanisms that lead to morphine dependency and withdrawal is oxidative stress. Recent research has shown that olive fruit oil contains phenolic compounds which have higher antioxidant properties. In current study, we are trying to explore the ability of Olea Europaea (Olive) fruit oil to increase the antioxidant activity level subsequently alleviate morphine dependence and withdrawal. Better understanding on the effect of olive fruit oil on oxidative stress produced by olive to morphine dependency and withdrawal need to be further explored especially on the cellular and molecular level.