Hybrid modelling of mechanical cues in cell migration

Hybrid modelling of mechanical cues in cell migration

Many studies stress the crucial importance of the mechanical component in angiogenesis, but still very few models really integrate mechanics. We propose to investigate the importance of mechanical cues for cell migration in this context with a new hybrid continuous-discrete model that describes the...

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Main Authors: Stéphanou Angélique, Le Floc’h Simon, Chauvière Arnaud
Format: Article
Language:English
Published: EDP Sciences 2015-01-01
Series:ITM Web of Conferences
Online Access:http://dx.doi.org/10.1051/itmconf/20150500012
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spelling doaj-a3ae94f4146f47ec913bf92f25dbe3f62021-03-02T08:59:05ZengEDP SciencesITM Web of Conferences2271-20972015-01-0150001210.1051/itmconf/20150500012itmconf_mod2015_00012Hybrid modelling of mechanical cues in cell migrationStéphanou Angélique0Le Floc’h Simon1Chauvière Arnaud2Université Grenoble Alpes, CNRS, TIMC-IMAG / DyCTiMUniversité de Montpellier IIUniversité Grenoble Alpes, CNRS, TIMC-IMAG / DyCTiMMany studies stress the crucial importance of the mechanical component in angiogenesis, but still very few models really integrate mechanics. We propose to investigate the importance of mechanical cues for cell migration in this context with a new hybrid continuous-discrete model that describes the individual migration of contracting cells on an elastic matrix of fibres. The matrix is described as a continuum substrate whereas the cells are described as discrete elements.http://dx.doi.org/10.1051/itmconf/20150500012
collection DOAJ
language English
format Article
sources DOAJ
author Stéphanou Angélique
Le Floc’h Simon
Chauvière Arnaud
spellingShingle Stéphanou Angélique
Le Floc’h Simon
Chauvière Arnaud
Hybrid modelling of mechanical cues in cell migration
ITM Web of Conferences
author_facet Stéphanou Angélique
Le Floc’h Simon
Chauvière Arnaud
author_sort Stéphanou Angélique
title Hybrid modelling of mechanical cues in cell migration
title_short Hybrid modelling of mechanical cues in cell migration
title_full Hybrid modelling of mechanical cues in cell migration
title_fullStr Hybrid modelling of mechanical cues in cell migration
title_full_unstemmed Hybrid modelling of mechanical cues in cell migration
title_sort hybrid modelling of mechanical cues in cell migration
publisher EDP Sciences
series ITM Web of Conferences
issn 2271-2097
publishDate 2015-01-01
description Many studies stress the crucial importance of the mechanical component in angiogenesis, but still very few models really integrate mechanics. We propose to investigate the importance of mechanical cues for cell migration in this context with a new hybrid continuous-discrete model that describes the individual migration of contracting cells on an elastic matrix of fibres. The matrix is described as a continuum substrate whereas the cells are described as discrete elements.
url http://dx.doi.org/10.1051/itmconf/20150500012
work_keys_str_mv AT stephanouangelique hybridmodellingofmechanicalcuesincellmigration
AT leflochsimon hybridmodellingofmechanicalcuesincellmigration
AT chauvierearnaud hybridmodellingofmechanicalcuesincellmigration
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