Synthetic Artificial Long Non-coding RNA Shows Higher Efficiency in Specific Malignant Phenotype Inhibition Compared to the CRISPR/Cas Systems

Synthetic Artificial Long Non-coding RNA Shows Higher Efficiency in Specific Malignant Phenotype Inhibition Compared to the CRISPR/Cas Systems

Objective: Both oncogenic transcription factors (TFs) and microRNAs (miRNAs) play an important regulator in human cancer by transcriptional and post-transcriptional regulation, respectively. These phenomena raise questions about the ability of artificial device to regulate miRNAs and TFs simultaneou...

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Bibliographic Details
Main Authors: Lin Yao, Quan Zhang, Aolin Li, Binglei Ma, Zhenan Zhang, Jun Liu, Lei Liang, Shiyu Zhu, Ying Gan, Qian Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Molecular Biosciences
Subjects:
bladder cancer
synthetic biology
aptamer
miRNA
transcription factors
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2020.617600/full

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