Acute appendicitis in acute leukemia and the potential role of decitabine in the critically ill patient

Acute appendicitis in acute leukemia and the potential role of decitabine in the critically ill patient

Acute appendicitis in children with acute leukemia is uncommon and often recognized late. Immunocompromised host state coupled with the importance of avoiding treatment delays makes management additionally challenging. Leukemic infiltration of the appendix though rare must also be considered. Althou...

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Main Authors: Deepti Warad, Mira A. Kohorst, Sadaf Altaf, Michael B. Ishitani, Shakila Khan, Vilmarie Rodriguez, Amulya A. Nageswara Rao
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Leukemia Research Reports
Subjects:
Acute appendicitis
Acute leukemia
Management
Decitabine
Online Access:http://www.sciencedirect.com/science/article/pii/S2213048914200227
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spelling doaj-a38d622ce7fe4aa8b35e5c805b5f14502020-11-24T21:08:06ZengElsevierLeukemia Research Reports2213-04892015-01-0141212310.1016/j.lrr.2015.03.001Acute appendicitis in acute leukemia and the potential role of decitabine in the critically ill patientDeepti Warad0Mira A. Kohorst1Sadaf Altaf2Michael B. Ishitani3Shakila Khan4Vilmarie Rodriguez5Amulya A. Nageswara Rao6Division of Pediatric Hematology-Oncology, Mayo Clinic, 200 First Street S.W., Rochester, MN, USADepartment of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USADepartment of Pediatric Hematology-Oncology, The Aga Khan University Hospital, Karachi, PakistanDivision of Pediatric Surgery, Mayo Clinic, Rochester, MN, USADivision of Pediatric Hematology-Oncology, Mayo Clinic, 200 First Street S.W., Rochester, MN, USADivision of Pediatric Hematology-Oncology, Mayo Clinic, 200 First Street S.W., Rochester, MN, USADivision of Pediatric Hematology-Oncology, Mayo Clinic, 200 First Street S.W., Rochester, MN, USAAcute appendicitis in children with acute leukemia is uncommon and often recognized late. Immunocompromised host state coupled with the importance of avoiding treatment delays makes management additionally challenging. Leukemic infiltration of the appendix though rare must also be considered. Although successful conservative management has been reported, surgical intervention is required in most cases. We present our experience with acute appendicitis in children with acute leukemia and a case of complete remission of acute myeloid leukemia with a short course of decitabine. Decitabine may serve as bridging therapy in critically ill patients who are unable to undergo intensive chemotherapy.http://www.sciencedirect.com/science/article/pii/S2213048914200227Acute appendicitisAcute leukemiaManagementDecitabine
collection DOAJ
language English
format Article
sources DOAJ
author Deepti Warad
Mira A. Kohorst
Sadaf Altaf
Michael B. Ishitani
Shakila Khan
Vilmarie Rodriguez
Amulya A. Nageswara Rao
spellingShingle Deepti Warad
Mira A. Kohorst
Sadaf Altaf
Michael B. Ishitani
Shakila Khan
Vilmarie Rodriguez
Amulya A. Nageswara Rao
Acute appendicitis in acute leukemia and the potential role of decitabine in the critically ill patient
Leukemia Research Reports
Acute appendicitis
Acute leukemia
Management
Decitabine
author_facet Deepti Warad
Mira A. Kohorst
Sadaf Altaf
Michael B. Ishitani
Shakila Khan
Vilmarie Rodriguez
Amulya A. Nageswara Rao
author_sort Deepti Warad
title Acute appendicitis in acute leukemia and the potential role of decitabine in the critically ill patient
title_short Acute appendicitis in acute leukemia and the potential role of decitabine in the critically ill patient
title_full Acute appendicitis in acute leukemia and the potential role of decitabine in the critically ill patient
title_fullStr Acute appendicitis in acute leukemia and the potential role of decitabine in the critically ill patient
title_full_unstemmed Acute appendicitis in acute leukemia and the potential role of decitabine in the critically ill patient
title_sort acute appendicitis in acute leukemia and the potential role of decitabine in the critically ill patient
publisher Elsevier
series Leukemia Research Reports
issn 2213-0489
publishDate 2015-01-01
description Acute appendicitis in children with acute leukemia is uncommon and often recognized late. Immunocompromised host state coupled with the importance of avoiding treatment delays makes management additionally challenging. Leukemic infiltration of the appendix though rare must also be considered. Although successful conservative management has been reported, surgical intervention is required in most cases. We present our experience with acute appendicitis in children with acute leukemia and a case of complete remission of acute myeloid leukemia with a short course of decitabine. Decitabine may serve as bridging therapy in critically ill patients who are unable to undergo intensive chemotherapy.
topic Acute appendicitis
Acute leukemia
Management
Decitabine
url http://www.sciencedirect.com/science/article/pii/S2213048914200227
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