TIGIT, the Next Step Towards Successful Combination Immune Checkpoint Therapy in Cancer

T cell immunoreceptor with Ig and ITIM domains (TIGIT) is an inhibitory receptor expressed on several types of lymphocytes. Efficacy of antibody blockade of TIGIT in cancer immunotherapy is currently widely being investigated in both pre-clinical and clinical studies. In multiple cancers TIGIT is ex...

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Bibliographic Details
Main Authors: Zhouhong Ge, Maikel P. Peppelenbosch, Dave Sprengers, Jaap Kwekkeboom
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.699895/full