Efficient Prostate Cancer Therapy with Tissue-Specific Homing Peptides Identified by Advanced Phage Display Technology

Selective targeting of drugs to tumor cells is a key goal in oncology. Here, we performed an in vivo phage display to identify peptides that specifically target xenografted prostate cancer cells. This yielded three peptide candidates, LN1 (C-TGTPARQ-C), LN2 (C-KNSMFAT-C), and LN3 (C-TNKHSPK-C); each...

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Bibliographic Details
Main Authors: Akinori Wada, Tomoya Terashima, Susumu Kageyama, Tetsuya Yoshida, Mitsuhiro Narita, Akihiro Kawauchi, Hideto Kojima
Format: Article
Language:English
Published: Elsevier 2019-03-01
Series:Molecular Therapy: Oncolytics
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770519300014