LncRNA-MIAT Increased in Patients with Coronary Atherosclerotic Heart Disease

Background. To study the expression and clinical significance of long noncoding RNA- (lncRNA-) MIAT in patients with coronary atherosclerotic heart disease (CAD). Methods. Serum MIAT, interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) in 106 CAD patients and 89 healthy donors were detected. C...

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Main Authors: Jin Tan, Shengzhong Liu, Qin Jiang, Tao Yu, Keli Huang
Format: Article
Language:English
Published: Hindawi Limited 2019-01-01
Series:Cardiology Research and Practice
Online Access:http://dx.doi.org/10.1155/2019/6280194
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spelling doaj-a38643d204634eeba86ef1e545e349cb2020-11-24T21:44:53ZengHindawi LimitedCardiology Research and Practice2090-80162090-05972019-01-01201910.1155/2019/62801946280194LncRNA-MIAT Increased in Patients with Coronary Atherosclerotic Heart DiseaseJin Tan0Shengzhong Liu1Qin Jiang2Tao Yu3Keli Huang4Cardiovascular Surgery Center, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu 610000, ChinaCardiovascular Surgery Center, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu 610000, ChinaCardiovascular Surgery Center, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu 610000, ChinaCardiovascular Surgery Center, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu 610000, ChinaCardiovascular Surgery Center, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu 610000, ChinaBackground. To study the expression and clinical significance of long noncoding RNA- (lncRNA-) MIAT in patients with coronary atherosclerotic heart disease (CAD). Methods. Serum MIAT, interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) in 106 CAD patients and 89 healthy donors were detected. Correlations between serum MIAT and serum IL-6 and TNF-α were analyzed. Risk factors for patients with CAD were analyzed by multiple factor analysis. Results. Compared with healthy donors, serum lncRNA-MIAT was significantly increased in CAD patients. Serum MIAT was positively correlated with serum IL-6 and TNF-α in CAD. Multivariate analysis found that hypertension (OR (95% CI) = 3.471 (2.180–4.091), P=0.011), diabetes (OR (95% CI) = 3.682 (1.698–4.897), P=0.003), HDL-C (OR (95% CI) = 3.372 (1.760–6.920), P=0.001), and serum MIAT expression (OR (95% CI) = 2.687 (1.683–7.468), P=0.001) were independent risk factors for CAD. Conclusions. Serum lncRNA-MIAT in CAD patients was significantly increased, which may be a potential marker for diagnosis and prognosis of CAD.http://dx.doi.org/10.1155/2019/6280194
collection DOAJ
language English
format Article
sources DOAJ
author Jin Tan
Shengzhong Liu
Qin Jiang
Tao Yu
Keli Huang
spellingShingle Jin Tan
Shengzhong Liu
Qin Jiang
Tao Yu
Keli Huang
LncRNA-MIAT Increased in Patients with Coronary Atherosclerotic Heart Disease
Cardiology Research and Practice
author_facet Jin Tan
Shengzhong Liu
Qin Jiang
Tao Yu
Keli Huang
author_sort Jin Tan
title LncRNA-MIAT Increased in Patients with Coronary Atherosclerotic Heart Disease
title_short LncRNA-MIAT Increased in Patients with Coronary Atherosclerotic Heart Disease
title_full LncRNA-MIAT Increased in Patients with Coronary Atherosclerotic Heart Disease
title_fullStr LncRNA-MIAT Increased in Patients with Coronary Atherosclerotic Heart Disease
title_full_unstemmed LncRNA-MIAT Increased in Patients with Coronary Atherosclerotic Heart Disease
title_sort lncrna-miat increased in patients with coronary atherosclerotic heart disease
publisher Hindawi Limited
series Cardiology Research and Practice
issn 2090-8016
2090-0597
publishDate 2019-01-01
description Background. To study the expression and clinical significance of long noncoding RNA- (lncRNA-) MIAT in patients with coronary atherosclerotic heart disease (CAD). Methods. Serum MIAT, interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) in 106 CAD patients and 89 healthy donors were detected. Correlations between serum MIAT and serum IL-6 and TNF-α were analyzed. Risk factors for patients with CAD were analyzed by multiple factor analysis. Results. Compared with healthy donors, serum lncRNA-MIAT was significantly increased in CAD patients. Serum MIAT was positively correlated with serum IL-6 and TNF-α in CAD. Multivariate analysis found that hypertension (OR (95% CI) = 3.471 (2.180–4.091), P=0.011), diabetes (OR (95% CI) = 3.682 (1.698–4.897), P=0.003), HDL-C (OR (95% CI) = 3.372 (1.760–6.920), P=0.001), and serum MIAT expression (OR (95% CI) = 2.687 (1.683–7.468), P=0.001) were independent risk factors for CAD. Conclusions. Serum lncRNA-MIAT in CAD patients was significantly increased, which may be a potential marker for diagnosis and prognosis of CAD.
url http://dx.doi.org/10.1155/2019/6280194
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