LncRNA-MIAT Increased in Patients with Coronary Atherosclerotic Heart Disease
Background. To study the expression and clinical significance of long noncoding RNA- (lncRNA-) MIAT in patients with coronary atherosclerotic heart disease (CAD). Methods. Serum MIAT, interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) in 106 CAD patients and 89 healthy donors were detected. C...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2019-01-01
|
Series: | Cardiology Research and Practice |
Online Access: | http://dx.doi.org/10.1155/2019/6280194 |
id |
doaj-a38643d204634eeba86ef1e545e349cb |
---|---|
record_format |
Article |
spelling |
doaj-a38643d204634eeba86ef1e545e349cb2020-11-24T21:44:53ZengHindawi LimitedCardiology Research and Practice2090-80162090-05972019-01-01201910.1155/2019/62801946280194LncRNA-MIAT Increased in Patients with Coronary Atherosclerotic Heart DiseaseJin Tan0Shengzhong Liu1Qin Jiang2Tao Yu3Keli Huang4Cardiovascular Surgery Center, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu 610000, ChinaCardiovascular Surgery Center, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu 610000, ChinaCardiovascular Surgery Center, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu 610000, ChinaCardiovascular Surgery Center, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu 610000, ChinaCardiovascular Surgery Center, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu 610000, ChinaBackground. To study the expression and clinical significance of long noncoding RNA- (lncRNA-) MIAT in patients with coronary atherosclerotic heart disease (CAD). Methods. Serum MIAT, interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) in 106 CAD patients and 89 healthy donors were detected. Correlations between serum MIAT and serum IL-6 and TNF-α were analyzed. Risk factors for patients with CAD were analyzed by multiple factor analysis. Results. Compared with healthy donors, serum lncRNA-MIAT was significantly increased in CAD patients. Serum MIAT was positively correlated with serum IL-6 and TNF-α in CAD. Multivariate analysis found that hypertension (OR (95% CI) = 3.471 (2.180–4.091), P=0.011), diabetes (OR (95% CI) = 3.682 (1.698–4.897), P=0.003), HDL-C (OR (95% CI) = 3.372 (1.760–6.920), P=0.001), and serum MIAT expression (OR (95% CI) = 2.687 (1.683–7.468), P=0.001) were independent risk factors for CAD. Conclusions. Serum lncRNA-MIAT in CAD patients was significantly increased, which may be a potential marker for diagnosis and prognosis of CAD.http://dx.doi.org/10.1155/2019/6280194 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jin Tan Shengzhong Liu Qin Jiang Tao Yu Keli Huang |
spellingShingle |
Jin Tan Shengzhong Liu Qin Jiang Tao Yu Keli Huang LncRNA-MIAT Increased in Patients with Coronary Atherosclerotic Heart Disease Cardiology Research and Practice |
author_facet |
Jin Tan Shengzhong Liu Qin Jiang Tao Yu Keli Huang |
author_sort |
Jin Tan |
title |
LncRNA-MIAT Increased in Patients with Coronary Atherosclerotic Heart Disease |
title_short |
LncRNA-MIAT Increased in Patients with Coronary Atherosclerotic Heart Disease |
title_full |
LncRNA-MIAT Increased in Patients with Coronary Atherosclerotic Heart Disease |
title_fullStr |
LncRNA-MIAT Increased in Patients with Coronary Atherosclerotic Heart Disease |
title_full_unstemmed |
LncRNA-MIAT Increased in Patients with Coronary Atherosclerotic Heart Disease |
title_sort |
lncrna-miat increased in patients with coronary atherosclerotic heart disease |
publisher |
Hindawi Limited |
series |
Cardiology Research and Practice |
issn |
2090-8016 2090-0597 |
publishDate |
2019-01-01 |
description |
Background. To study the expression and clinical significance of long noncoding RNA- (lncRNA-) MIAT in patients with coronary atherosclerotic heart disease (CAD). Methods. Serum MIAT, interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) in 106 CAD patients and 89 healthy donors were detected. Correlations between serum MIAT and serum IL-6 and TNF-α were analyzed. Risk factors for patients with CAD were analyzed by multiple factor analysis. Results. Compared with healthy donors, serum lncRNA-MIAT was significantly increased in CAD patients. Serum MIAT was positively correlated with serum IL-6 and TNF-α in CAD. Multivariate analysis found that hypertension (OR (95% CI) = 3.471 (2.180–4.091), P=0.011), diabetes (OR (95% CI) = 3.682 (1.698–4.897), P=0.003), HDL-C (OR (95% CI) = 3.372 (1.760–6.920), P=0.001), and serum MIAT expression (OR (95% CI) = 2.687 (1.683–7.468), P=0.001) were independent risk factors for CAD. Conclusions. Serum lncRNA-MIAT in CAD patients was significantly increased, which may be a potential marker for diagnosis and prognosis of CAD. |
url |
http://dx.doi.org/10.1155/2019/6280194 |
work_keys_str_mv |
AT jintan lncrnamiatincreasedinpatientswithcoronaryatheroscleroticheartdisease AT shengzhongliu lncrnamiatincreasedinpatientswithcoronaryatheroscleroticheartdisease AT qinjiang lncrnamiatincreasedinpatientswithcoronaryatheroscleroticheartdisease AT taoyu lncrnamiatincreasedinpatientswithcoronaryatheroscleroticheartdisease AT kelihuang lncrnamiatincreasedinpatientswithcoronaryatheroscleroticheartdisease |
_version_ |
1725908183050878976 |