Two-hit Hypothesis and Multiple Organ Dysfunction Syndrome
A severe insult in the form of infection or trauma primes the host immune system so that a subsequent, relatively trivial insult produces a markedly exaggerated host immune response, which can lead to multiple organ dysfunction syndrome (MODS) and death. This forms the basis of the “two-hit hypothe...
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Nepal Medical Association
2008-04-01
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| Series: | Journal of Nepal Medical Association |
| Online Access: | http://jnma.com.np/jnma/index.php/jnma/article/view/318 |
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doaj-a3862b954b3c4f26b08395bdae0e18862020-11-25T01:44:56ZengNepal Medical AssociationJournal of Nepal Medical Association0028-27151815-672X2008-04-014717010.31729/jnma.318Two-hit Hypothesis and Multiple Organ Dysfunction SyndromeI Butt0Badri Man Shrestha1Sheffield Kidney Institute Herries Road, Sheffield, S5 7AU, UKSheffield Kidney Institute Herries Road, Sheffield, S5 7AU, UK A severe insult in the form of infection or trauma primes the host immune system so that a subsequent, relatively trivial insult produces a markedly exaggerated host immune response, which can lead to multiple organ dysfunction syndrome (MODS) and death. This forms the basis of the “two-hit hypothesis” (THH), which is being increasingly recognised as an important cause of morbidity and mortality following severe injury and sepsis, particularly in intensive care settings. Appreciation of the impact ofrepeatedinsults andpathophysiology of MODS is vital in the prevention of this serious complication. We describe a case which illustrates the concept of THH and MODS and present a review of literature on this subject. Key words: laparotomy, multiple organ dysfunction, sepsis, two-hit hypothesis http://jnma.com.np/jnma/index.php/jnma/article/view/318 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
I Butt Badri Man Shrestha |
| spellingShingle |
I Butt Badri Man Shrestha Two-hit Hypothesis and Multiple Organ Dysfunction Syndrome Journal of Nepal Medical Association |
| author_facet |
I Butt Badri Man Shrestha |
| author_sort |
I Butt |
| title |
Two-hit Hypothesis and Multiple Organ Dysfunction Syndrome |
| title_short |
Two-hit Hypothesis and Multiple Organ Dysfunction Syndrome |
| title_full |
Two-hit Hypothesis and Multiple Organ Dysfunction Syndrome |
| title_fullStr |
Two-hit Hypothesis and Multiple Organ Dysfunction Syndrome |
| title_full_unstemmed |
Two-hit Hypothesis and Multiple Organ Dysfunction Syndrome |
| title_sort |
two-hit hypothesis and multiple organ dysfunction syndrome |
| publisher |
Nepal Medical Association |
| series |
Journal of Nepal Medical Association |
| issn |
0028-2715 1815-672X |
| publishDate |
2008-04-01 |
| description |
A severe insult in the form of infection or trauma primes the host immune system so that a subsequent,
relatively trivial insult produces a markedly exaggerated host immune response, which can lead
to multiple organ dysfunction syndrome (MODS) and death. This forms the basis of the “two-hit
hypothesis” (THH), which is being increasingly recognised as an important cause of morbidity and
mortality following severe injury and sepsis, particularly in intensive care settings. Appreciation of
the impact ofrepeatedinsults andpathophysiology of MODS is vital in the prevention of this serious
complication. We describe a case which illustrates the concept of THH and MODS and present a
review of literature on this subject.
Key words: laparotomy, multiple organ dysfunction, sepsis, two-hit hypothesis
|
| url |
http://jnma.com.np/jnma/index.php/jnma/article/view/318 |
| work_keys_str_mv |
AT ibutt twohithypothesisandmultipleorgandysfunctionsyndrome AT badrimanshrestha twohithypothesisandmultipleorgandysfunctionsyndrome |
| _version_ |
1725026157045219328 |