Shelterin complex gene: Prognosis and therapeutic vulnerability in cancer

Shelterin complex gene: Prognosis and therapeutic vulnerability in cancer

Telomere encompasses a (TTAGGG)n tandem repeats, and its dysfunction has emerged as the epicenter of driving carcinogenesis by promoting genetic instability. Indeed, they play an essential role in stabilizing chromosomes and therefore protecting them from end-to-end fusion and DNA degradation. Telom...

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Bibliographic Details
Main Authors: Vikas Kumar Bhari, Durgesh Kumar, Surendra Kumar, Rajeev Mishra
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Biochemistry and Biophysics Reports
Subjects:
Telomere
DNA damage
hTERT
Shelterin complex
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580821000315

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