Noninvasive Relative Quantification of [11C]ABP688 PET Imaging in Mice Versus an Input Function Measured Over an Arteriovenous Shunt

Noninvasive Relative Quantification of [11C]ABP688 PET Imaging in Mice Versus an Input Function Measured Over an Arteriovenous Shunt

Impairment of the metabotropic glutamate receptor 5 (mGluR5) has been implicated with various neurologic disorders. Although mGluR5 density can be quantified with the PET radiotracer [11C]ABP688, the methods for reproducible quantification of [11C]ABP688 PET imaging in mice have not been thoroughly...

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Bibliographic Details
Main Authors: Jeroen Verhaeghe, Daniele Bertoglio, Lauren Kosten, David Thomae, Marleen Verhoye, Annemie Van Der Linden, Leonie Wyffels, Sigrid Stroobants, John Wityak, Celia Dominguez, Ladislav Mrzljak, Steven Staelens
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Neurology
Subjects:
[11C]ABP688
input function
mGluR5
PET imaging
test-retest
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2018.00516/full

Internet

https://www.frontiersin.org/article/10.3389/fneur.2018.00516/full

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