Mutation in the loop C-terminal to the cyclophilin A binding site of HIV-1 capsid protein disrupts proper virus assembly and infectivity

Mutation in the loop C-terminal to the cyclophilin A binding site of HIV-1 capsid protein disrupts proper virus assembly and infectivity

<p>Abstract</p> <p>We have studied the effects associated with two single amino acid substitution mutations in HIV-1 capsid (CA), the E98A and E187G. Both amino acids are well conserved among all major HIV-1 subtypes. HIV-1 infectivity is critically dependent on proper CA cone form...

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Bibliographic Details
Main Authors: Höglund Anders, Höglund Stefan, Abdurahman Samir, Vahlne Anders
Format: Article
Language:English
Published: BMC 2007-03-01
Series:Retrovirology
Online Access:http://www.retrovirology.com/content/4/1/19

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