Prolonged plasma glucose elevation on oral glucose tolerance test in young healthy Japanese individuals

• Main Authors: Hirotaka Ishigaki, Akihiro Yoshida, Osamu Araki, Takao Kimura, Katsuhiko Tsunekawa, Yoshifumi Shoho, Makoto Nara, Tomoyuki Aoki, Takayuki Ogiwara, Masami Murakami
• Format: Article
• Language: English
• Published: Wiley 2020-01-01
• Series: Endocrinology, Diabetes & Metabolism
• Subjects: disposition index; high‐density lipoprotein cholesterol; insulin secretion; oral glucose tolerance test; young Japanese
• Online Access: https://doi.org/10.1002/edm2.98
• ISSN: 2398-9238

Abstract Aims This study aims to assess insulin secretion and resistance through oral glucose tolerance test (OGTT) among young Japanese individuals. Subjects and methods We enrolled 595 young healthy Japanese individuals aged 22‐29 years. They underwent an OGTT, and their results were divided into 4 groups (I‐IV), according to the time at which their plasma glucose concentration declined below the fasting glucose concentration (30, 60 or 120 minutes or never as groups I, II, III and IV, respectively). Results We classified 575 normal glucose‐tolerant subjects into 4 groups (I‐IV) with I: 28 (4.9%), II: 120 (20.9%), III: 143 (24.9%) and IV: 284 (49.4%) individuals. The Matsuda, insulinogenic and disposition indices were decreased from groups I to IV. ROC curves of disposition index reflecting the composition of insulin secretion and sensitivity classified the prolonged glucose elevation group (group III + IV) from the rapid glucose lowering group (group II; AUC = 0.847). Conclusions Even in a young and healthy Japanese individual within the physiological range of glycaemic control, there is a sequential decrease in insulin sensitivity and secretion.