Potential Role of MicroRNAs in the Regulation of Antiviral Responses to Influenza Infection

Influenza is a major health burden worldwide and is caused by influenza viruses that are enveloped and negative stranded RNA viruses. Little progress has been achieved in targeted intervention, either at a population level or at an individual level (to treat the cause), due to the toxicity of drugs...

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Main Authors:	Thi Hiep Nguyen, Xiaoming Liu, Zhen Zhong Su, Alan Chen-Yu Hsu, Paul S. Foster, Ming Yang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-07-01
Series:	Frontiers in Immunology
Subjects:	microRNA immune responses influenza virus infection inflammation
Online Access:	https://www.frontiersin.org/article/10.3389/fimmu.2018.01541/full

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spelling	doaj-a378815540c5474e98e5e370757139562020-11-24T20:43:33ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-07-01910.3389/fimmu.2018.01541380350Potential Role of MicroRNAs in the Regulation of Antiviral Responses to Influenza InfectionThi Hiep Nguyen0Thi Hiep Nguyen1Xiaoming Liu2Xiaoming Liu3Zhen Zhong Su4Alan Chen-Yu Hsu5Alan Chen-Yu Hsu6Paul S. Foster7Paul S. Foster8Ming Yang9Ming Yang10Priority Research Centre for Healthy Lungs, The University of Newcastle, Callaghan, NSW, AustraliaFaculty of Health and Medicine, School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW, AustraliaPriority Research Centre for Healthy Lungs, The University of Newcastle, Callaghan, NSW, AustraliaFaculty of Health and Medicine, School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW, AustraliaDepartment of Respiratory Medicine, The Second Hospital, Jilin University, ChangChun, ChinaPriority Research Centre for Healthy Lungs, The University of Newcastle, Callaghan, NSW, AustraliaFaculty of Health and Medicine, School of Medicine and Public Health, The University of Newcastle, Callaghan, NSW, AustraliaPriority Research Centre for Healthy Lungs, The University of Newcastle, Callaghan, NSW, AustraliaFaculty of Health and Medicine, School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW, AustraliaPriority Research Centre for Healthy Lungs, The University of Newcastle, Callaghan, NSW, AustraliaFaculty of Health and Medicine, School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW, AustraliaInfluenza is a major health burden worldwide and is caused by influenza viruses that are enveloped and negative stranded RNA viruses. Little progress has been achieved in targeted intervention, either at a population level or at an individual level (to treat the cause), due to the toxicity of drugs and ineffective vaccines against influenza viruses. MicroRNAs (miRNAs) are small non-coding RNAs that play critical roles in gene expression, cell differentiation, and tissue development and have been shown to silence viral replication in a sequence-specific manner. Investigation of these small endogenous nucleotides may lead to new therapeutics against influenza virus infection. Here, we describe our current understanding of the role of miRNAs in host defense response against influenza virus, as well as their potential and limitation as new therapeutic approaches.https://www.frontiersin.org/article/10.3389/fimmu.2018.01541/fullmicroRNAimmune responsesinfluenza virusinfectioninflammation
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Thi Hiep Nguyen Thi Hiep Nguyen Xiaoming Liu Xiaoming Liu Zhen Zhong Su Alan Chen-Yu Hsu Alan Chen-Yu Hsu Paul S. Foster Paul S. Foster Ming Yang Ming Yang
spellingShingle	Thi Hiep Nguyen Thi Hiep Nguyen Xiaoming Liu Xiaoming Liu Zhen Zhong Su Alan Chen-Yu Hsu Alan Chen-Yu Hsu Paul S. Foster Paul S. Foster Ming Yang Ming Yang Potential Role of MicroRNAs in the Regulation of Antiviral Responses to Influenza Infection Frontiers in Immunology microRNA immune responses influenza virus infection inflammation
author_facet	Thi Hiep Nguyen Thi Hiep Nguyen Xiaoming Liu Xiaoming Liu Zhen Zhong Su Alan Chen-Yu Hsu Alan Chen-Yu Hsu Paul S. Foster Paul S. Foster Ming Yang Ming Yang
author_sort	Thi Hiep Nguyen
title	Potential Role of MicroRNAs in the Regulation of Antiviral Responses to Influenza Infection
title_short	Potential Role of MicroRNAs in the Regulation of Antiviral Responses to Influenza Infection
title_full	Potential Role of MicroRNAs in the Regulation of Antiviral Responses to Influenza Infection
title_fullStr	Potential Role of MicroRNAs in the Regulation of Antiviral Responses to Influenza Infection
title_full_unstemmed	Potential Role of MicroRNAs in the Regulation of Antiviral Responses to Influenza Infection
title_sort	potential role of micrornas in the regulation of antiviral responses to influenza infection
publisher	Frontiers Media S.A.
series	Frontiers in Immunology
issn	1664-3224
publishDate	2018-07-01
description	Influenza is a major health burden worldwide and is caused by influenza viruses that are enveloped and negative stranded RNA viruses. Little progress has been achieved in targeted intervention, either at a population level or at an individual level (to treat the cause), due to the toxicity of drugs and ineffective vaccines against influenza viruses. MicroRNAs (miRNAs) are small non-coding RNAs that play critical roles in gene expression, cell differentiation, and tissue development and have been shown to silence viral replication in a sequence-specific manner. Investigation of these small endogenous nucleotides may lead to new therapeutics against influenza virus infection. Here, we describe our current understanding of the role of miRNAs in host defense response against influenza virus, as well as their potential and limitation as new therapeutic approaches.
topic	microRNA immune responses influenza virus infection inflammation
url	https://www.frontiersin.org/article/10.3389/fimmu.2018.01541/full
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Potential Role of MicroRNAs in the Regulation of Antiviral Responses to Influenza Infection

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