Spermine-Related DNA Hypermethylation and Elevated Expression of Genes for Collagen Formation are Susceptible Factors for Chemotherapy-Induced Hand-Foot Syndrome in Chinese Colorectal Cancer Patients

Spermine-Related DNA Hypermethylation and Elevated Expression of Genes for Collagen Formation are Susceptible Factors for Chemotherapy-Induced Hand-Foot Syndrome in Chinese Colorectal Cancer Patients

Hand-foot syndrome (HFS) is a common capecitabine-based chemotherapy-related adverse event (CRAE) in patients with colorectal cancer (CRC). It is of great significance to comprehensively identify susceptible factors for HFS, and further to elucidate the biomolecular mechanism of HFS susceptibility....

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Bibliographic Details
Main Authors: Mingming Li, Jiani Chen, Shaoqun Liu, Xiaomeng Sun, Huilin Xu, Qianmin Gao, Xintao Chen, Chaowen Xi, Doudou Huang, Yi Deng, Feng Zhang, Shouhong Gao, Shi Qiu, Xia Tao, Jingwen Zhai, Hua Wei, Houshan Yao, Wansheng Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Pharmacology
Subjects:
adverse effects
chemotherapy
DNA methylation
hand-foot syndrome
immune response
multi-omics
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.746910/full

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