A pro-inflammatory mediator USP11 enhances the stability of p53 and inhibits KLF2 in intracerebral hemorrhage

A pro-inflammatory mediator USP11 enhances the stability of p53 and inhibits KLF2 in intracerebral hemorrhage

Microglial cell activation and neuroinflammation after intracerebral hemorrhage (ICH) lead to secondary brain damage. Ubiquitin-specific protease 11 (USP11) has been correlated with ICH-induced neuron apoptosis. This study aims to explore the molecular mechanism of USP11 regulating neuroinflammation...

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Bibliographic Details
Main Authors: Xiuqing Zhang, Tiejun Liu, Shijun Xu, Peng Gao, Wei Dong, Weiran Liu, Ming Gao, Lihua Song, Lusha Cui, Xiaoliu Dong
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
intracerebral hemorrhage
ubiquitin-specific protease 11
p53
Kruppel-like factor 2
NF-κB pathway
neuroinflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050121000152

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