Properties of an Oral Preparation Containing a Chitosan Salt

• Main Authors: Susumu Kawashima, Kyouko Kofuji, Daijirou Hirai, Youko Kodama, Yoshifumi Murata
• Format: Article
• Language: English
• Published: MDPI AG 2009-02-01
• Series: Molecules
• Subjects: Chitosan; 2-(4-Chlorophenoxy)-2-methylpropionic acid; Bile acid adsorption; Drug release; Hyperlipidemia
• Online Access: http://www.mdpi.com/1420-3049/14/2/755/

The 2-(4-chlorophenoxy)-2-methylpropionic acid (CMP) salt of chitosan (CS), CS-CMP, and that of a CS derivative (CP), were prepared and their ability to adsorb bile acids investigated. CS-CMP and CP-CMP rapidly adsorbed taurocholate (TCA) and glycocholate (GCA) when these bile acids were present together in the medium, with simultaneous release of CMP. A secondary bile acid, taurodeoxycholate, was preferentially adsorbed over TCA and GCA. Alginate gel beads containing CS-CMP did not differ from CS-CMP alone in their manner of bile acids take up. Furthermore, oral administration of CS-CMP to rats resulted in decreased serum cholesterol and triacylglycerol levels for two weeks. Therefore, CS-CMP, as well as a vehiclecontaining CS-CMP, might be a useful agent with which to treat hyperlipidemia