Modeling the Spatiotemporal Dynamics of Light and Heat Propagation for In Vivo Optogenetics

Despite the increasing use of optogenetics in vivo, the effects of direct light exposure to brain tissue are understudied. Of particular concern is the potential for heat induced by prolonged optical stimulation. We demonstrate that high-intensity light, delivered through an optical fiber, is capabl...

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Bibliographic Details
Main Authors: Joseph M. Stujenske, Timothy Spellman, Joshua A. Gordon
Format: Article
Language:English
Published: Elsevier 2015-07-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715006488