Applying linear and non-linear methods for parallel prediction of volume of distribution and fraction of unbound drug.

Applying linear and non-linear methods for parallel prediction of volume of distribution and fraction of unbound drug.

Volume of distribution and fraction unbound are two key parameters in pharmacokinetics. The fraction unbound describes the portion of free drug in plasma that may extravasate, while volume of distribution describes the tissue access and binding of a drug. Reliable in silico predictions of these phar...

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Bibliographic Details
Main Authors: Eva M del Amo, Leo Ghemtio, Henri Xhaard, Marjo Yliperttula, Arto Urtti, Heidi Kidron
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3792104?pdf=render

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