Laboratory Stock Variants of the Archetype Silver Resistance Plasmid pMG101 Demonstrate Plasmid Fusion, Loss of Transmissibility, and Transposition of Tn7/pco/sil Into the Host Chromosome

Laboratory Stock Variants of the Archetype Silver Resistance Plasmid pMG101 Demonstrate Plasmid Fusion, Loss of Transmissibility, and Transposition of Tn7/pco/sil Into the Host Chromosome

Salmonella Typhimurium carrying the multidrug resistance (MDR) plasmid pMG101 was isolated from three burns patients in Boston United States in 1973. pMG101 was transferrable into other Salmonella spp. and Escherichia coli hosts and carried what was a novel and unusual combination of AMR genes and s...

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Bibliographic Details
Main Authors: Steven P.T. Hooton, Alexander C.W. Pritchard, Karishma Asiani, Charlotte J. Gray-Hammerton, Dov J. Stekel, Lisa C. Crossman, Andrew D. Millard, Jon L. Hobman
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Microbiology
Subjects:
plasmid
silver resistance
pMG101
PacBio
recombination
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.723322/full

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