Immunization with the Malaria Diversity-Covering Blood-Stage Vaccine Candidate Plasmodium falciparum Apical Membrane Antigen 1 DiCo in Complex with Its Natural Ligand PfRon2 Does Not Improve the In Vitro Efficacy

Immunization with the Malaria Diversity-Covering Blood-Stage Vaccine Candidate Plasmodium falciparum Apical Membrane Antigen 1 DiCo in Complex with Its Natural Ligand PfRon2 Does Not Improve the In Vitro Efficacy

The blood-stage malaria vaccine candidate Plasmodium falciparum apical membrane antigen 1 (PfAMA1) can induce strong parasite growth-inhibitory antibody responses in animals but has not achieved the anticipated efficacy in clinical trials. Possible explanations in humans are the insufficient potency...

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Bibliographic Details
Main Authors: Holger Spiegel, Alexander Boes, Rolf Fendel, Andreas Reimann, Stefan Schillberg, Rainer Fischer
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Immunology
Subjects:
agroinfiltration
growth inhibition assay
plant molecular farming
Plasmodium falciparum
strain-transcending immune responses
surface plasmon resonance spectroscopy
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00743/full

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