Cyclosporine modulates neutrophil functions via the SIRT6–HIF‐1α–glycolysis axis to alleviate severe ulcerative colitis

Cyclosporine modulates neutrophil functions via the SIRT6–HIF‐1α–glycolysis axis to alleviate severe ulcerative colitis

Abstract Background Cyclosporine A (CsA) is routinely used to treat patients with steroid‐refractory acute severe ulcerative colitis (ASUC). Here, we studied the underlying mechanisms of CsA‐mediated alleviation in ASUC patients. Methods Neutrophil functions including expression of cytokines, apopto...

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Bibliographic Details
Main Authors: Huiying Lu, Jian Lin, Chunjin Xu, Mingming Sun, Keqiang Zuo, Xiaoping Zhang, Mingsong Li, Hailiang Huang, Zhong Li, Wei Wu, Baisui Feng, Zhanju Liu
Format: Article
Language:English
Published: Wiley 2021-02-01
Series:Clinical and Translational Medicine
Subjects:
glycolysis
neutrophil
SIRT6
ulcerative colitis
Online Access:https://doi.org/10.1002/ctm2.334

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