Attenuated TGFB signalling in macrophages decreases susceptibility to DMBA-induced mammary cancer in mice

Attenuated TGFB signalling in macrophages decreases susceptibility to DMBA-induced mammary cancer in mice

Abstract Background Transforming growth factor beta1 (TGFB1) is a multi-functional cytokine that regulates mammary gland development and cancer progression through endocrine, paracrine and autocrine mechanisms. TGFB1 also plays roles in tumour development and progression, and its increased expressio...

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Bibliographic Details
Main Authors: Xuan Sun, Sarah M. Bernhardt, Danielle J. Glynn, Leigh J. Hodson, Lucy Woolford, Andreas Evdokiou, Cong Yan, Hong Du, Sarah A. Robertson, Wendy V. Ingman
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Breast Cancer Research
Subjects:
Transforming growth factor beta
Mammary gland
Macrophage
Cancer
Online Access:https://doi.org/10.1186/s13058-021-01417-8

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