The JAK2/STAT3/CCND2 Axis promotes colorectal Cancer stem cell persistence and radioresistance

The JAK2/STAT3/CCND2 Axis promotes colorectal Cancer stem cell persistence and radioresistance

Abstract Background Radiotherapy (RT) is a highly effective multimodal nonsurgical treatment that is essential for patients with advanced colorectal cancer (CRC). Nevertheless, cell subpopulations displaying intrinsic radioresistance survive after RT. The reactivation of their proliferation and succ...

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Bibliographic Details
Main Authors: So-Yeon Park, Choong-Jae Lee, Jang-Hyun Choi, Jee-Heun Kim, Ji-Won Kim, Ji-Young Kim, Jeong-Seok Nam
Format: Article
Language:English
Published: BMC 2019-09-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Colorectal cancer (CRC)
Radioresistance
Janus kinase 2 (JAK2)
Signal transducer and activator of transcription 3 (STAT3)
Cyclin D2 (CCND2)
Cancer stem cells (CSCs)
Online Access:http://link.springer.com/article/10.1186/s13046-019-1405-7

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http://link.springer.com/article/10.1186/s13046-019-1405-7

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