Research progress of microglia in eye disease

Research progress of microglia in eye disease

Microglia are the resident macrophages of the central nervous system(CNS). Microglia constantly monitor the pathological changes of the surrounding microenvironment. Activated microglia play key roles in tissue protection and injury under the stimulation of various injury factors. Abnormal activatio...

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Main Authors: Ling Cui*, Guang-Yi Huang*, Fan Xu
Format: Article
Language:English
Published: Press of International Journal of Ophthalmology (IJO PRESS) 2020-03-01
Series:Guoji Yanke Zazhi
Subjects:
microglia
optic nerve injury
diabetic retinopathy
glaucoma
targeted therapy
basic research
Online Access:http://ies.ijo.cn/cn_publish/2020/3/202003014.pdf
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spelling doaj-a330b7f89b484423ad5f6293d0df779d2020-11-25T02:28:23ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51231672-51232020-03-0120347247610.3980/j.issn.1672-5123.2020.3.14Research progress of microglia in eye diseaseLing Cui*0Guang-Yi Huang*1Fan Xu2Department of Ophthalmology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, Guangxi Zhuang Autonomous Region, ChinaCo-first authors: Ling Cui and Guang-Yi Huang.Department of Ophthalmology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, Guangxi Zhuang Autonomous Region, ChinaCo-first authors: Ling Cui and Guang-Yi Huang.Department of Ophthalmology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, Guangxi Zhuang Autonomous Region, ChinaCo-first authors: Ling Cui and Guang-Yi Huang.Microglia are the resident macrophages of the central nervous system(CNS). Microglia constantly monitor the pathological changes of the surrounding microenvironment. Activated microglia play key roles in tissue protection and injury under the stimulation of various injury factors. Abnormal activation of microglia mediates retinal inflammation and aggravates the original ophthalmic diseases. Our growing understanding of the mechanisms of the interaction between microglia and retinal cells is identifying potential cellular and molecular targets for therapeutic interventions that may be apply to optic nerve injury, diabetic retinopathy, glaucoma and other diseases in the future. In this review, potential links between ophthalmic diseases and microglial activity will be explored.http://ies.ijo.cn/cn_publish/2020/3/202003014.pdfmicrogliaoptic nerve injurydiabetic retinopathyglaucomatargeted therapybasic research
collection DOAJ
language English
format Article
sources DOAJ
author Ling Cui*
Guang-Yi Huang*
Fan Xu
spellingShingle Ling Cui*
Guang-Yi Huang*
Fan Xu
Research progress of microglia in eye disease
Guoji Yanke Zazhi
microglia
optic nerve injury
diabetic retinopathy
glaucoma
targeted therapy
basic research
author_facet Ling Cui*
Guang-Yi Huang*
Fan Xu
author_sort Ling Cui*
title Research progress of microglia in eye disease
title_short Research progress of microglia in eye disease
title_full Research progress of microglia in eye disease
title_fullStr Research progress of microglia in eye disease
title_full_unstemmed Research progress of microglia in eye disease
title_sort research progress of microglia in eye disease
publisher Press of International Journal of Ophthalmology (IJO PRESS)
series Guoji Yanke Zazhi
issn 1672-5123
1672-5123
publishDate 2020-03-01
description Microglia are the resident macrophages of the central nervous system(CNS). Microglia constantly monitor the pathological changes of the surrounding microenvironment. Activated microglia play key roles in tissue protection and injury under the stimulation of various injury factors. Abnormal activation of microglia mediates retinal inflammation and aggravates the original ophthalmic diseases. Our growing understanding of the mechanisms of the interaction between microglia and retinal cells is identifying potential cellular and molecular targets for therapeutic interventions that may be apply to optic nerve injury, diabetic retinopathy, glaucoma and other diseases in the future. In this review, potential links between ophthalmic diseases and microglial activity will be explored.
topic microglia
optic nerve injury
diabetic retinopathy
glaucoma
targeted therapy
basic research
url http://ies.ijo.cn/cn_publish/2020/3/202003014.pdf
work_keys_str_mv AT lingcui researchprogressofmicrogliaineyedisease
AT guangyihuang researchprogressofmicrogliaineyedisease
AT fanxu researchprogressofmicrogliaineyedisease
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