Measurement of Poly(ADP-ribose) Level with Enhanced Slot Blot Assay with Crosslinking

Measurement of Poly(ADP-ribose) Level with Enhanced Slot Blot Assay with Crosslinking

Poly(ADP-ribose) (PAR) formation is catalyzed by poly(ADP-ribose) polymerase (PARP) family proteins in nuclei as well as in cytosols. The anti-PAR antibodies that specifically detect PAR are useful for the quantitative measurement of PAR in cells, in tissue, and in the body. In clinical trials of PA...

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Bibliographic Details
Main Authors: Yuko Kudo, Yuka Sasaki, Takae Onodera, Jun Hashimoto, Tadashige Nozaki, Kenji Tamura, Masatoshi Watanabe, Mitsuko Masutani
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Challenges
Subjects:
poly(ADP-ribose)
PARP inhibitor
pharmacodynamic assay
UV crosslink
Online Access:http://www.mdpi.com/2078-1547/9/2/27

Internet

http://www.mdpi.com/2078-1547/9/2/27

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