PAP and NT5E inhibit nociceptive neurotransmission by rapidly hydrolyzing nucleotides to adenosine

PAP and NT5E inhibit nociceptive neurotransmission by rapidly hydrolyzing nucleotides to adenosine

<p>Abstract</p> <p>Background</p> <p>Prostatic acid phosphatase (PAP) and ecto-5'-nucleotidase (NT5E, CD73) produce extracellular adenosine from the nucleotide AMP in spinal nociceptive (pain-sensing) circuits; however, it is currently unknown if these are the main...

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Bibliographic Details
Main Authors: Vihko Pirkko, Guillot Thomas S, Taylor-Blake Bonnie, Sowa Nathaniel A, Walsh Paul L, Street Sarah E, Wightman R Mark, Zylka Mark J
Format: Article
Language:English
Published: SAGE Publishing 2011-10-01
Series:Molecular Pain
Subjects:
pain
nociception
ectonucleotidase
adenosine
fast-scan cyclic voltammetry
field recordings
Online Access:http://www.molecularpain.com/content/7/1/80

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