Primary

• Main Authors: Mahmoud Abbas, Mario W. Kramer, Tilmann Spieker, Thomas R.W. Herrman, Axel S. Merseburger, Klaus-Michael Müller, Marcus A. Kuczyk, Jan U. Becker, Hans-Heinrich Kreipe
• Format: Article
• Language: English
• Published: SpringerOpen 2014-03-01
• Series: Journal of the Egyptian National Cancer Institute
• Subjects: Adenocarcinoma; Renal pevis; Carcinoma in situ; Ureter
• Online Access: http://www.sciencedirect.com/science/article/pii/S1110036213001118

Primary epithelial tumor of the renal pelvis is rare and only 100 cases are reported in the literature [1]. Histological examination of the tumor showed glands, cysts, and papillae lined by pseudostratified columnar epithelium with hyperchromatic nuclei. Scattered signet ring-type cells were also seen floating in large pools of extracellular mucin. Sections from the ureter showed a component of adenocarcinoma in situ. No invasive tumor was identified in ureteric tissue. One case was reported with carcinoma in situ of the ureter (2). Immunohistochemically: The tumor showed positivity for CK7, CK20, CK8/18, GATA-3, MSH-2, MSH-6, MLH-1, Ber-EP4, and S-100-P with focal positivity for CDX-2, weak positivity for PMS-2 and negativity in TTF-1 and Her-2. Molecular pathological analysis revealed microsatellite stability and without mutation in K-ras-gene. Thus, a diagnosis of mucinous adenocarcinoma of the renal pelvis with in situ adenocarcinoma of the ureter was made.