Clinical and microbiological characteristics of recurrent group B streptococcal infection among non-pregnant adults

• Main Authors: Ying-Hsiang Wang, Hung-Ming Chen, Yun-Hsuan Yang, Tsung-Han Yang, Ching-Hao Teng, Chyi-Liang Chen, Chishih Chu, Cheng-Hsun Chiu
• Format: Article
• Language: English
• Published: Elsevier 2014-09-01
• Series: International Journal of Infectious Diseases
• Subjects: Group B streptococci; Recurrent; Serotype; Antimicrobial resistance
• Online Access: http://www.sciencedirect.com/science/article/pii/S1201971214015549
• ISSN: 1201-9712; 1878-3511

Objective: This study aimed to investigate the clinical and microbiological features of recurrent group B streptococcal (GBS) diseases among non-pregnant adults. Methods: All hospitalized non-pregnant adults who had culture-proven GBS infections between January 2008 and December 2010 were enrolled in this retrospective study. Bacterial isolates were examined for their serotypes, genotypes, and antimicrobial resistance. Results: The recurrence rate of GBS infection in Taiwan was found to be 9.3%. Of the 70 recurrent episodes in 32 patients, infections of the urinary tract (U) were diagnosed clinically in 55.7%, infections of the soft tissue (S) in 31.4%, and infections of the bloodstream (B) in 12.9%. The initial/recurrent episodes in 25 patients were mainly U/U (40.6%), followed by S/S (18.8%) and B/B (6.2%). The serotypes/serogroups identified were serotypes V (34.3%), Ib (22.9%), VI (17.1%), III (12.9%), IV (7.1%), and Ia (5.7%). Recurrent strains showed less resistance to erythromycin or clindamycin than non-recurrent strains. Six distinct genotypes were identified in 12 serotype VI isolates derived from seven patients; five of these isolate pairs had identical genotypes. Conclusions: Recurrent GBS diseases were found to occur considerably more often than previously thought, mainly in adults with a high comorbid index. Relapse, not new acquisition, was found to be more common.