A green and efficient protocol for the synthesis of dihydropyrano[2,3-c]pyrazole derivatives via a one-pot, four component reaction by grinding method

A green and efficient protocol for the synthesis of dihydropyrano[2,3-c]pyrazole derivatives via a one-pot, four component reaction by grinding method

An efficient grinding protocol for the synthesis of dihydropyrano[2,3-c]pyrazole derivatives from acetylene ester, hydrazine hydrate, aryl aldehydes and malononitrile under solvent free conditions has been achieved with excellent yields. The structures of the synthesized compounds were deduced by sp...

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Main Authors: Sethurajan Ambethkar, Vediappen Padmini, Nattamai Bhuvanesh
Format: Article
Language:English
Published: Elsevier 2015-11-01
Series:Journal of Advanced Research
Subjects:
Pyranopyrazole
Multicomponent
Grinding
Antioxidant
Antimicrobial
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123214001441
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spelling doaj-a2f0662b9190431ebcb4a0bb68791f1d2020-11-24T23:03:47ZengElsevierJournal of Advanced Research2090-12322090-12242015-11-016697598510.1016/j.jare.2014.11.011A green and efficient protocol for the synthesis of dihydropyrano[2,3-c]pyrazole derivatives via a one-pot, four component reaction by grinding methodSethurajan Ambethkar0Vediappen Padmini1Nattamai Bhuvanesh2Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai 625021, Tamil Nadu, IndiaDepartment of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai 625021, Tamil Nadu, IndiaX-ray Diffraction Laboratory, Department of Chemistry, Texas A&M University, College Station, TX 77842, USAAn efficient grinding protocol for the synthesis of dihydropyrano[2,3-c]pyrazole derivatives from acetylene ester, hydrazine hydrate, aryl aldehydes and malononitrile under solvent free conditions has been achieved with excellent yields. The structures of the synthesized compounds were deduced by spectroscopic techniques and the compounds were further evaluated for their in vitro antioxidant and antimicrobial activities.http://www.sciencedirect.com/science/article/pii/S2090123214001441PyranopyrazoleMulticomponentGrindingAntioxidantAntimicrobial
collection DOAJ
language English
format Article
sources DOAJ
author Sethurajan Ambethkar
Vediappen Padmini
Nattamai Bhuvanesh
spellingShingle Sethurajan Ambethkar
Vediappen Padmini
Nattamai Bhuvanesh
A green and efficient protocol for the synthesis of dihydropyrano[2,3-c]pyrazole derivatives via a one-pot, four component reaction by grinding method
Journal of Advanced Research
Pyranopyrazole
Multicomponent
Grinding
Antioxidant
Antimicrobial
author_facet Sethurajan Ambethkar
Vediappen Padmini
Nattamai Bhuvanesh
author_sort Sethurajan Ambethkar
title A green and efficient protocol for the synthesis of dihydropyrano[2,3-c]pyrazole derivatives via a one-pot, four component reaction by grinding method
title_short A green and efficient protocol for the synthesis of dihydropyrano[2,3-c]pyrazole derivatives via a one-pot, four component reaction by grinding method
title_full A green and efficient protocol for the synthesis of dihydropyrano[2,3-c]pyrazole derivatives via a one-pot, four component reaction by grinding method
title_fullStr A green and efficient protocol for the synthesis of dihydropyrano[2,3-c]pyrazole derivatives via a one-pot, four component reaction by grinding method
title_full_unstemmed A green and efficient protocol for the synthesis of dihydropyrano[2,3-c]pyrazole derivatives via a one-pot, four component reaction by grinding method
title_sort green and efficient protocol for the synthesis of dihydropyrano[2,3-c]pyrazole derivatives via a one-pot, four component reaction by grinding method
publisher Elsevier
series Journal of Advanced Research
issn 2090-1232
2090-1224
publishDate 2015-11-01
description An efficient grinding protocol for the synthesis of dihydropyrano[2,3-c]pyrazole derivatives from acetylene ester, hydrazine hydrate, aryl aldehydes and malononitrile under solvent free conditions has been achieved with excellent yields. The structures of the synthesized compounds were deduced by spectroscopic techniques and the compounds were further evaluated for their in vitro antioxidant and antimicrobial activities.
topic Pyranopyrazole
Multicomponent
Grinding
Antioxidant
Antimicrobial
url http://www.sciencedirect.com/science/article/pii/S2090123214001441
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AT vediappenpadmini agreenandefficientprotocolforthesynthesisofdihydropyrano23cpyrazolederivativesviaaonepotfourcomponentreactionbygrindingmethod
AT nattamaibhuvanesh agreenandefficientprotocolforthesynthesisofdihydropyrano23cpyrazolederivativesviaaonepotfourcomponentreactionbygrindingmethod
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