Self-assembled single-atom nanozyme for enhanced photodynamic therapy treatment of tumor

The hypoxic microenvironment in solid tumors limits the efficacy of photodynamic therapy (PDT) since oxygen is necessary to produce high cytotoxic singlet oxygen species. Here, the authors develop an improved self-assembled single-atom nanozyme which allows oxygen generation to enhance PDT efficacy.

Bibliographic Details
Main Authors:	Dongdong Wang, Huihui Wu, Soo Zeng Fiona Phua, Guangbao Yang, Wei Qi Lim, Long Gu, Cheng Qian, Haibao Wang, Zhen Guo, Hongzhong Chen, Yanli Zhao
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-14199-7

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spelling	doaj-a2ef257ac4894317964ca7d79d63039f2021-05-11T08:41:57ZengNature Publishing GroupNature Communications2041-17232020-01-0111111310.1038/s41467-019-14199-7Self-assembled single-atom nanozyme for enhanced photodynamic therapy treatment of tumorDongdong Wang0Huihui Wu1Soo Zeng Fiona Phua2Guangbao Yang3Wei Qi Lim4Long Gu5Cheng Qian6Haibao Wang7Zhen Guo8Hongzhong Chen9Yanli Zhao10Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological UniversityAnhui Key Laboratory for Cellular Dynamics and Chemical Biology, School of Life Sciences, University of Science and Technology of ChinaDivision of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological UniversityDivision of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological UniversityDivision of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological UniversityDivision of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological UniversityDivision of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological UniversityRadiology Department of the First Affiliated Hospital of Anhui Medical UniversityAnhui Key Laboratory for Cellular Dynamics and Chemical Biology, School of Life Sciences, University of Science and Technology of ChinaDivision of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological UniversityDivision of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological UniversityThe hypoxic microenvironment in solid tumors limits the efficacy of photodynamic therapy (PDT) since oxygen is necessary to produce high cytotoxic singlet oxygen species. Here, the authors develop an improved self-assembled single-atom nanozyme which allows oxygen generation to enhance PDT efficacy.https://doi.org/10.1038/s41467-019-14199-7
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Dongdong Wang Huihui Wu Soo Zeng Fiona Phua Guangbao Yang Wei Qi Lim Long Gu Cheng Qian Haibao Wang Zhen Guo Hongzhong Chen Yanli Zhao
spellingShingle	Dongdong Wang Huihui Wu Soo Zeng Fiona Phua Guangbao Yang Wei Qi Lim Long Gu Cheng Qian Haibao Wang Zhen Guo Hongzhong Chen Yanli Zhao Self-assembled single-atom nanozyme for enhanced photodynamic therapy treatment of tumor Nature Communications
author_facet	Dongdong Wang Huihui Wu Soo Zeng Fiona Phua Guangbao Yang Wei Qi Lim Long Gu Cheng Qian Haibao Wang Zhen Guo Hongzhong Chen Yanli Zhao
author_sort	Dongdong Wang
title	Self-assembled single-atom nanozyme for enhanced photodynamic therapy treatment of tumor
title_short	Self-assembled single-atom nanozyme for enhanced photodynamic therapy treatment of tumor
title_full	Self-assembled single-atom nanozyme for enhanced photodynamic therapy treatment of tumor
title_fullStr	Self-assembled single-atom nanozyme for enhanced photodynamic therapy treatment of tumor
title_full_unstemmed	Self-assembled single-atom nanozyme for enhanced photodynamic therapy treatment of tumor
title_sort	self-assembled single-atom nanozyme for enhanced photodynamic therapy treatment of tumor
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-01-01
description	The hypoxic microenvironment in solid tumors limits the efficacy of photodynamic therapy (PDT) since oxygen is necessary to produce high cytotoxic singlet oxygen species. Here, the authors develop an improved self-assembled single-atom nanozyme which allows oxygen generation to enhance PDT efficacy.
url	https://doi.org/10.1038/s41467-019-14199-7
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Self-assembled single-atom nanozyme for enhanced photodynamic therapy treatment of tumor

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