Circulating Lactonase Activity but Not Protein Level of PON-1 Predicts Adverse Outcomes in Subjects with Chronic Kidney Disease

Circulating Lactonase Activity but Not Protein Level of PON-1 Predicts Adverse Outcomes in Subjects with Chronic Kidney Disease

The burden of cardiovascular disease and death in chronic kidney disease (CKD) outpaces that of the other diseases and is not adequately described by traditional risk factors alone. Diminished activity of paraoxonase (PON)-1 is associated with increased oxidant stress, a common feature underlying th...

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Bibliographic Details
Main Authors: Chrysan J. Mohammed, Yanmei Xie, Pamela S. Brewster, Subhanwita Ghosh, Prabhatchandra Dube, Tiana Sarsour, Andrew L. Kleinhenz, Erin L. Crawford, Deepak Malhotra, Richard W. James, Philip A. Kalra, Steven T. Haller, David J. Kennedy
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Journal of Clinical Medicine
Subjects:
paraoxonase
lactonase activity
chronic kidney disease
clinical outcomes
Online Access:https://www.mdpi.com/2077-0383/8/7/1034

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https://www.mdpi.com/2077-0383/8/7/1034

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