Exploration of metformin as novel therapy for osteoarthritis: preventing cartilage degeneration and reducing pain behavior

Exploration of metformin as novel therapy for osteoarthritis: preventing cartilage degeneration and reducing pain behavior

Abstract Background Metformin could activate adenosine monophosphate-activated protein kinase (AMPK) which was postulated as a potential therapeutic target for osteoarthritis. This study aimed to examine the effects of metformin on cartilage and pain in osteoarthritis mouse model. Methods Eighty 10-...

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Bibliographic Details
Main Authors: Hui Li, Xiang Ding, Robert Terkeltaub, Hang Lin, Yuqing Zhang, Bin Zhou, Ke He, Kun Li, Zhichen Liu, Jie Wei, Yuanheng Yang, Hui Xie, Chao Zeng, Guanghua Lei
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Arthritis Research & Therapy
Subjects:
Osteoarthritis
Metformin
Mice
AMPK
Online Access:http://link.springer.com/article/10.1186/s13075-020-2129-y

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