Racemization of Serine Residues Catalyzed by Dihydrogen Phosphate Ion: A Computational Study

Spontaneous, nonenzymatic reactions in proteins are known to have relevance to aging and age-related diseases, such as cataract and Alzheimer’s disease. Among such reactions is the racemization of Ser residues, but its mechanism in vivo remains to be clarified. The most likely intermediate is an eno...

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Bibliographic Details
Main Authors: Ohgi Takahashi, Ryota Kirikoshi, Noriyoshi Manabe
Format: Article
Language:English
Published: MDPI AG 2017-11-01
Series:Catalysts
Subjects:
Online Access:https://www.mdpi.com/2073-4344/7/12/363