An anionic phthalocyanine decreases NRAS expression by breaking down its RNA G-quadruplex

An anionic phthalocyanine decreases NRAS expression by breaking down its RNA G-quadruplex

Hyperactivity of the gene NRAS contributes to the proliferation and metastatic nature of many types of cancer cells. Here, the authors show that NRAS can be controlled by an anionic phthalocyanine coordinating Zn2+ in combination with photo-irradiation.

Bibliographic Details
Main Authors: Keiko Kawauchi, Wataru Sugimoto, Takatoshi Yasui, Kohei Murata, Katsuhiko Itoh, Kazuki Takagi, Takaaki Tsuruoka, Kensuke Akamatsu, Hisae Tateishi-Karimata, Naoki Sugimoto, Daisuke Miyoshi
Format: Article
Language:English
Published: Nature Publishing Group 2018-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-04771-y
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spelling doaj-a2b986b81e324fa785914b0394c35e222021-05-11T09:46:31ZengNature Publishing GroupNature Communications2041-17232018-06-019111210.1038/s41467-018-04771-yAn anionic phthalocyanine decreases NRAS expression by breaking down its RNA G-quadruplexKeiko Kawauchi0Wataru Sugimoto1Takatoshi Yasui2Kohei Murata3Katsuhiko Itoh4Kazuki Takagi5Takaaki Tsuruoka6Kensuke Akamatsu7Hisae Tateishi-Karimata8Naoki Sugimoto9Daisuke Miyoshi10Faculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan UniversityFaculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan UniversityFaculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan UniversityFaculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan UniversityFaculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan UniversityFaculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan UniversityFaculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan UniversityFaculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan UniversityFrontier Institute for Biomolecular Engineering Research (FIBER), Konan UniversityFrontier Institute for Biomolecular Engineering Research (FIBER), Konan UniversityFaculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan UniversityHyperactivity of the gene NRAS contributes to the proliferation and metastatic nature of many types of cancer cells. Here, the authors show that NRAS can be controlled by an anionic phthalocyanine coordinating Zn2+ in combination with photo-irradiation.https://doi.org/10.1038/s41467-018-04771-y
collection DOAJ
language English
format Article
sources DOAJ
author Keiko Kawauchi
Wataru Sugimoto
Takatoshi Yasui
Kohei Murata
Katsuhiko Itoh
Kazuki Takagi
Takaaki Tsuruoka
Kensuke Akamatsu
Hisae Tateishi-Karimata
Naoki Sugimoto
Daisuke Miyoshi
spellingShingle Keiko Kawauchi
Wataru Sugimoto
Takatoshi Yasui
Kohei Murata
Katsuhiko Itoh
Kazuki Takagi
Takaaki Tsuruoka
Kensuke Akamatsu
Hisae Tateishi-Karimata
Naoki Sugimoto
Daisuke Miyoshi
An anionic phthalocyanine decreases NRAS expression by breaking down its RNA G-quadruplex
Nature Communications
author_facet Keiko Kawauchi
Wataru Sugimoto
Takatoshi Yasui
Kohei Murata
Katsuhiko Itoh
Kazuki Takagi
Takaaki Tsuruoka
Kensuke Akamatsu
Hisae Tateishi-Karimata
Naoki Sugimoto
Daisuke Miyoshi
author_sort Keiko Kawauchi
title An anionic phthalocyanine decreases NRAS expression by breaking down its RNA G-quadruplex
title_short An anionic phthalocyanine decreases NRAS expression by breaking down its RNA G-quadruplex
title_full An anionic phthalocyanine decreases NRAS expression by breaking down its RNA G-quadruplex
title_fullStr An anionic phthalocyanine decreases NRAS expression by breaking down its RNA G-quadruplex
title_full_unstemmed An anionic phthalocyanine decreases NRAS expression by breaking down its RNA G-quadruplex
title_sort anionic phthalocyanine decreases nras expression by breaking down its rna g-quadruplex
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-06-01
description Hyperactivity of the gene NRAS contributes to the proliferation and metastatic nature of many types of cancer cells. Here, the authors show that NRAS can be controlled by an anionic phthalocyanine coordinating Zn2+ in combination with photo-irradiation.
url https://doi.org/10.1038/s41467-018-04771-y
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