Optimization of HIV-1 Envelope DNA Vaccine Candidates within Three Different Animal Models, Guinea Pigs, Rabbits and Cynomolgus Macaques

Optimization of HIV-1 Envelope DNA Vaccine Candidates within Three Different Animal Models, Guinea Pigs, Rabbits and Cynomolgus Macaques

HIV-1 DNA vaccines have many advantageous features. Evaluation of HIV-1 vaccine candidates often starts in small animal models before macaque and human trials. Here, we selected and optimized DNA vaccine candidates through systematic testing in rabbits for the induction of broadly neutralizing antib...

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Bibliographic Details
Main Authors: Roger Le Grand, Anders Fomsgaard, Marianne Jansson, Leo Heyndrickx, Gabriella Scarlatti, Priscilla Biswas, Guillaume Stewart-Jones, Emma Joanne Bowles, Nathalie Dereuddre-Bosquet, Frédéric Martinon, Rogier W Sanders, Mark Melchers, Tara Laura Elvang, Betina Skovgaard Andresen, Berit Grevstad, Johanna Repits, Marie Borggren, Lasse Vinner
Format: Article
Language:English
Published: MDPI AG 2013-07-01
Series:Vaccines
Subjects:
DNA vaccine
HIV-1
animal models
envelope
neutralizing antibodies
Online Access:http://www.mdpi.com/2076-393X/1/3/305

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